منابع مشابه
Cyclosporin for severe ulcerative colitis.
BACKGROUND About one-third of patients with severe ulcerative colitis do not respond to conventional therapy and require urgent colectomy. It was recently shown that cyclosporin is effective in some of these patients. OBJECTIVES To review the current experience of six hospitals in central Israel that used cyclosporin in patients with severe ulcerative colitis. METHODS The files of all 32 pa...
متن کاملCyclosporin for refractory ulcerative colitis.
Approximately 15% of patients with ulcerative colitis will have a severe attack requiring hospitalisation for intravenous steroids at some stage in their illness. Sixty per cent of patients treated with corticosteroids will be symptom free by the end of five days, 15% will have significant improvement, and 25% will not improve. Those who fail to improve may be treated with intravenous cyclospor...
متن کاملCyclosporin A-Induced Hyperlipidemia
Cyclosporin A (CsA) is an immunosuppressant drug widely used in organ transplant recipients and patients with auto-immune disorders. Long-term treatment with CsA is associated with hyperlipidemia and an increased risk of atherosclerosis. The mechanisms by which cyclosporin A causes hyperlipidemia are unclear. Cell and animal studies have pointed to various mechanisms that may mediate CsA-induce...
متن کاملCyclosporin-induced hypertension.
Introduction: Hypertension has emerged as a serious adverse effect of immunosuppression with cyclosporin, which has become the mainstay of immunosuppression in organ transplantation. Improved survival rates with cyclosporin compared to previous regimens based on corticosteroids and azathioprine were established and have led to an expansion of solid organ transplantation. Cyclosporin has also be...
متن کاملCyclosporin A-Induced Hyperreninemic Hypoaldosteronism
We studied the effects of cyclosporin A on the renin-aldosterone axis in SpragueDawley rats. Two weeks of intragastric administration of cyclosporin A (5 mg/kg/day or 20 mg/kg/day) resulted in large increases in plasma renin concentration (23 ± 5, 70 ±12, and 79 ± 11 ng/ml/hr in control rats and rats receiving 5 mg and 20 mg of cyclosporin A, respectively), with no parallel increments in plasma...
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ژورنال
عنوان ژورنال: BMJ
سال: 1993
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.307.6902.484-b